Concepts in Clinical Pharmacokinetics, 4th Edition

Book Description:
Leading investigators synthesize the entire
laboratory and clinical process of developing anticancer drugs to create a
single indispensable reference that covers all the steps from the identification
of cancer-specific targets to phase III
clinical trials. These expert authors provide their best guidance on a wide
variety of issues, including clinical trial design, preclinical screening, and
the development and validation of bioanalytic methods. The chapters on
identifying agents to test in phase III trials and on trial design for the
approval of new anticancer agents offer a unique roadmap for moving an agent to
NDA submission.
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Pharmacokinetics and Metabolism in Drug
Design (Methods & Principles in Medicinal Chemistry)

by Dennis A. Smith








Pharmacokinetics and Metabolism in Drug
Design (Methods and Principles in Medicinal Chemistry)
By Dennis A.
Smith, Han van de Waterbeemd, Don K. Walker

• Publisher: Wiley-VCH
  
• Number Of Pages: 160
  
• Publication Date: 2001-01-09
  
• ISBN-10
  / ASIN: 3527301976
  
• ISBN-13 / EAN: 9783527301973
  
• Binding: Hardcover
  

Book Description:

The medical benefits of a
drug are not only dependent on its biological effect, but also on its "life cycle"
within the organism - from its absorption
into the blood, distribution to tissue until its eventual breakdown or excretion
by the liver and kidneys.
Here, the authors, all of them employed at Pfizer
in the discovery and development of new active substances, discuss the
significant parameters and processes important for the absorption, distribution
and retention of drug compounds in the body, plus the potential problems created
by their transformation into toxic byproducts. The authors cover everything from
the fundamental principles right up to the latest developments using high
throughput methods to analyze the pharmacokinetic properties of active
substances.
Particular emphasis is placed on the impact of pharmacokinetic
parameters on the discovery of new drugs - one of the most challenging tasks in
global pharmaceutical research.
Thus,
this book is aimed at all those dealing professionally with the development and
application of pharmaceutical substances. Furthermore, the readily
comprehensible style of writing makes it equally suitable for students of pharmacy
and related subjects, who feel that pharmacokinetics is covered too briefly in
the standard textbooks.


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